Pdro, a Protein Associated with Late Endosomes and Lysosomes and Implicated in Cellular Cholesterol Homeostasis

201024 citationsJournal Articlegold Open Access

Authors

P. Guillaumot · Centre National de la Recherche Scientifique

Céline Luquain · Inserm

Mouhannad Malek · Centre Léon Bérard

Anne‐Laure Huber · Centre Léon Bérard

Sabine Brugière · CEA Grenoble

Jérôme Garin · Université Joseph Fourier

Didier Grünwald ·

Abstract

LDL-derived cholesterol release involves LE/LY motility that is linked to actin dynamics. Because Pdro regulates these two processes, we propose that modulation of Pdro expression in response to sterol levels regulates LDL-derived cholesterol through both LDL uptake and LE/LY dynamics, to ultimately control free cholesterol homeostasis.

Topics & Keywords

Cellular transport and secretion Lipid Membrane Structure and Behavior Protein Kinase Regulation and GTPase Signaling

Publication Details

Published in: PLoS ONE

Volume 5, Issue 6, pp. e10977-e10977

DOI: 10.1371/journal.pone.0010977

Field-Weighted Citation Impact: 1.47

Command Palette

Pdro, a Protein Associated with Late Endosomes and Lysosomes and Implicated in Cellular Cholesterol Homeostasis

Authors

Abstract

Topics & Keywords

Publication Details