Attenuation of Compensation of Endogenous Cardiac Natriuretic Peptide System in Chronic Heart Failure

1997961 citationsJournal Article

Authors

Takayoshi Tsutamoto · Shiga University of Medical Science

Atsuyuki Wada · Shiga University of Medical Science

Keiko Maeda · Shiga University of Medical Science

Tomoko Hisanaga · Shiga University of Medical Science

Yukiharu Maeda · Shiga University of Medical Science

Daisuke Fukai · Shiga University of Medical Science

Masato Ohnishi

Abstract

These findings indicate that plasma BNP is more useful than ANP for assessing the mortality in patients with chronic CHF and that the plasma levels of BNP provide prognostic information independent of other variables previously associated with a poor prognosis. Our findings also suggest that the compensatory activity of the cardiac natriuretic peptide system is attenuated as mortality increases in chronic CHF patients with high plasma levels of ANP and BNP.

Topics & Keywords

Heart Failure Treatment and Management Cardiac Structural Anomalies and Repair Cardiovascular Function and Risk Factors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 96, Issue 2, pp. 509-516

DOI: 10.1161/01.cir.96.2.509

Field-Weighted Citation Impact: 13.56