miR‐545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG‐I

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer‐related causes of death. Deregulation or dysfunction of miRNAs contribute to cancer development. In this study, we found that low miR‐545 level and high RIG‐I protein in PDAC tissues were both correlated with low survival rate. MiR‐545 up‐regulation inhibited PDAC cell lines growth and vice versa. 3′UTR of RIG‐I was targeted by miR‐545. Thus we concluded that low miR‐545 levels in PDAC promote tumor cells growth, and this is associated with reduced survival in PDAC patients. MiR‐545 exerts its effects by directly targeting RIG‐1.