Macrophages Inhibit Neovascularization in a Murine Model of Age-Related Macular Degeneration

2006261 citationsJournal Articlegold Open Access

Authors

Rajendra S. Apte · Washington University in St. Louis

Jennifer Richter · Washington University in St. Louis

John M. Herndon · Washington University in St. Louis

Thomas A. Ferguson · Washington University in St. Louis

Abstract

Immune vascular interactions can be highly complex. Normal macrophage function is critical in controlling pathologic neovascularization in the eye. IL-10 regulates macrophage activity in the eye and is an attractive therapeutic target in order to suppress or inhibit CNV in AMD that can otherwise lead to blindness.

Topics & Keywords

Retinal Diseases and Treatments Neuroinflammation and Neurodegeneration Mechanisms Ocular Diseases and Behçet’s Syndrome

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 3, Issue 8, pp. e310-e310

DOI: 10.1371/journal.pmed.0030310

Field-Weighted Citation Impact: 8.59

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