Claudins and the Modulation of Tight Junction Permeability

20131,407 citationsReview

Authors

Dorothee Günzel · Charité - Universitätsmedizin Berlin

Alan S.L. Yu · University of Kansas Medical Center

Abstract

Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability. This review summarizes our current knowledge of this large protein family and discusses recent advances in our understanding of their structure and physiological functions.

Topics & Keywords

Barrier Structure and Function Studies Connexins and lens biology Cancer-related molecular mechanisms research

Publication Details

Published in: Physiological Reviews

Volume 93, Issue 2, pp. 525-569

DOI: 10.1152/physrev.00019.2012

Field-Weighted Citation Impact: 46.54

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Claudins and the Modulation of Tight Junction Permeability

Authors

Abstract

Topics & Keywords

Publication Details