Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril

2006199 citationsJournal Article

Authors

Kiyoshi Maeda · Tottori University Hospital

Ichiro Ieiri · The University of Tokyo

Kiyomi Yasuda · The University of Tokyo

Aiko Fujino · Tokyo Fuji University

Hironobu Fujiwara · The University of Tokyo

Kohei Otsubo · The University of Tokyo

Mayumi Hirano ·

Abstract

The major clearance mechanism of pravastatin, valsartan, and temocapril appears to be similar, and OATP1B1*1b is one of the determinant factors governing the interindividual variability in the pharmacokinetics of pravastatin and, possibly, valsartan and temocapril.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Antibiotics Pharmacokinetics and Efficacy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 79, Issue 5, pp. 427-439

DOI: 10.1016/j.clpt.2006.01.011

Field-Weighted Citation Impact: 9.61