Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

201435 citationsJournal Articlehybrid Open Access

Authors

Claudia Percivalle · University of Pavia

Claudia Sissi · University of Padua

Maria Laura Greco · University of Padua

Caterina Musetti · University of Padua

Angelica Mariani · University of Pavia

Anna Artese · Magna Graecia University

Giosuè Costa ·

Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.

Topics & Keywords

DNA and Nucleic Acid Chemistry Advanced biosensing and bioanalysis techniques RNA and protein synthesis mechanisms

Publication Details

Published in: Organic & Biomolecular Chemistry

Volume 12, Issue 22, pp. 3744-3754

DOI: 10.1039/c4ob00220b

Field-Weighted Citation Impact: 1.99

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Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

Authors

Abstract

Topics & Keywords

Publication Details