Misoprostol Reduces Serious Gastrointestinal Complications in Patients with Rheumatoid Arthritis Receiving Nonsteroidal Anti-Inflammatory Drugs

19951,061 citationsJournal Article

Authors

Fred E. Silverstein · Baylor University

David Y. Graham · Baylor University

John R. Senior · Baylor University

Helen Wyn Davies · Baylor University

Barbara J. Struthers · Baylor University

Richard M. Bittman · Baylor University

G. Steven Geis · Baylor University

Abstract

In older patients with rheumatoid arthritis, misoprostol reduced serious NSAID-induced upper gastrointestinal complications by 40% compared with placebo.

Topics & Keywords

Pathogenesis and Treatment of Hiccups Inflammatory mediators and NSAID effects Pharmacy and Medical Practices

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Internal Medicine

Volume 123, Issue 4, pp. 241-249

DOI: 10.7326/0003-4819-123-4-199508150-00001

Field-Weighted Citation Impact: 23.57