Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells

201088 citationsJournal Articlegreen Open Access

Authors

Young Bin Hong · Georgetown University Medical Center

Hyo Jin Kang · Georgetown University

Sun Young Kwon · Georgetown University Medical Center

Hee Jeong Kim · Georgetown University

Kun Young Kwon

Chi Heum Cho

Jongmin Lee · Georgetown University Medical Center

Bhaskar Kallakury

Abstract

Because the intrinsic drug resistance of pancreatic cancers is, in part, due to abnormally elevated Nrf2 protein levels, further research on regulating Nrf2 activity may result in the development of novel pancreatic cancer therapies.

Topics & Keywords

Genomics, phytochemicals, and oxidative stress Glutathione Transferases and Polymorphisms Drug Transport and Resistance Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Pancreas

Volume 39, Issue 4, pp. 463-472

DOI: 10.1097/mpa.0b013e3181c31314

Field-Weighted Citation Impact: 2.64