Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3

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Authors

Mitchell C. Coleman · University of Iowa

Alicia K. Olivier · University of Iowa

James A. Jacobus · University of Iowa

Kranti A. Mapuskar · University of Iowa

Gaowei Mao · University of Iowa

Sean M. Martin · University of Iowa

Dennis P. Riley ·

Abstract

These results support the hypothesis that O2(•-) mediates acute liver injury in SIRT3(-/-) animals exposed to whole-body γ-radiation and suggest that GC4401 could be used as a radio-protective compound in vivo.

Topics & Keywords

Sirtuins and Resveratrol in Medicine Biochemical effects in animals Heme Oxygenase-1 and Carbon Monoxide

Publication Details

Published in: Antioxidants and Redox Signaling

Volume 20, Issue 9, pp. 1423-1435

DOI: 10.1089/ars.2012.5091

Field-Weighted Citation Impact: 1.48

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Superoxide Mediates Acute Liver Injury in Irradiated Mice Lacking Sirtuin 3

Authors

Abstract

Topics & Keywords

Publication Details