Endotoxin Exposure, CD14, and Allergic Disease

2006284 citationsJournal Article

Authors

Angela Simpson · University of Manchester

Sally John · University of Manchester

Francine Jury · University of Manchester

Robert Niven · University of Manchester

Ashley Woodcock · University of Manchester

William Ollier · University of Manchester

Adnan Ćustović ·

Abstract

Increasing endotoxin exposure is associated with reduced risk of allergic sensitization and eczema but with increased risk of nonatopic wheeze in children with the CC genotype at -159 of the CD14 gene. The impact of environmental endotoxin may be enhanced in individuals with this genotype.

Topics & Keywords

Asthma and respiratory diseases Indoor Air Quality and Microbial Exposure Pediatric health and respiratory diseases

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 174, Issue 4, pp. 386-392

DOI: 10.1164/rccm.200509-1380oc

Field-Weighted Citation Impact: 18.43

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Endotoxin Exposure, CD14, and Allergic Disease

Authors

Abstract

Topics & Keywords

Publication Details