The Rpd3/Hda1 family of histone deacetylases regulates azole resistance in <i>Candida albicans</i>

201560 citationsJournal Article

Authors

Xiaofang Li

Qing Cai · Shanghai Stomatological Hospital

Huan Mei

Xiaowei Zhou

Yongnian Shen

Dongmei Li · Georgetown University Medical Center

Weida Liu

Abstract

Our results indicate the important role of the Rpd3/Hda1 family in the development of azole resistance in C. albicans. Histone deacetylation may govern the expression of genes related to the early stages of adaptation to azole stress, such as efflux pump genes.

Topics & Keywords

Antifungal resistance and susceptibility Histone Deacetylase Inhibitors Research Fungal Infections and Studies

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 70, Issue 7, pp. 1993-2003

DOI: 10.1093/jac/dkv070

Field-Weighted Citation Impact: 2.33

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The Rpd3/Hda1 family of histone deacetylases regulates azole resistance in <i>Candida albicans</i>

Authors

Abstract

Topics & Keywords

Publication Details