Prevalence of Pathogenic BRCA1 Mutation Carriers in 5 US Racial/Ethnic Groups

2007329 citationsJournal Article

Authors

Esther M. John · Cancer Prevention Institute of California

Alexander Miron · Dana-Farber Cancer Institute

Gail Gong · Stanford University

Amanda I. Phipps · Cancer Prevention Institute of California

Anna Felberg · Stanford University

Frederick P. Li · Dana-Farber Cancer Institute

Dee W. West

Abstract

Among African American, Asian American, and Hispanic patients in the Northern California Breast Cancer Family Registry, the prevalence of BRCA1 mutation carriers was highest in Hispanics and lowest in Asian Americans. The higher carrier prevalence in Hispanics may reflect the presence of unrecognized Jewish ancestry in this population.

Topics & Keywords

BRCA gene mutations in cancer Genomic variations and chromosomal abnormalities DNA Repair Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA

Volume 298, Issue 24, pp. 2869-2869

DOI: 10.1001/jama.298.24.2869

Field-Weighted Citation Impact: 11.04