Feasibility of glucose monitoring based on Brownian dynamics in time-domain optical coherence tomography

Our purpose is to investigate the feasibility of Brownian motion in time-domain optical coherence tomography (OCT) incorporated with wavelet power spectrum to monitor glucose concentration in Intralipid solution. The results show that the standard deviation (SD) of frequency in the superficial layer of single scattering region, linearly proportional to Brownian diffusion coefficient, is independent of the depth. Our preliminary results demonstrate that average SD of frequency in the single scattering region is inversely proportional to the glucose concentration in Intralipid solution, since the Brownian diffusion coefficient is a function of concentration. Thus the average SD of frequency in OCT signal is capable of differentiating the glucose concentration.