Bone induction by <i>BMP‐2</i> transduced stem cells derived from human fat

2003339 citationsJournal Article

Authors

Jason L. Dragoo · University of California, Los Angeles

Joon Young Choi

Jay R. Lieberman · University of California, Los Angeles

Jerry I. Huang

Patricia A. Zuk

Jeffery Zhang · University of California, Los Angeles

Marc H. Hedrick

Prosper Benhaim · University of California, Los Angeles

Abstract

Liposuction aspirates contain PLAs that can be transfected with the BMP-2 gene, with rapid induction into the osteoblast phenotype at a rate comparable to rh-BMP-2 and osteoblast groups. Transduced PLAs produce more bone precursors with faster onset of calcified extracellular matrix than transduced BMAs. PLAs may be an ideal source of mesenchyme-lineage stem cells for gene therapy and tissue engineering.

Topics & Keywords

Mesenchymal stem cell research Bone fractures and treatments Cancer Cells and Metastasis

Publication Details

Published in: Journal of Orthopaedic Research®

Volume 21, Issue 4, pp. 622-629

DOI: 10.1016/s0736-0266(02)00238-3

Field-Weighted Citation Impact: 11.45

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Bone induction by <i>BMP‐2</i> transduced stem cells derived from human fat

Authors

Abstract

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Publication Details