Prognostic Value of Immunocytologic Detection of Bone Marrow Metastases in Neuroblastoma

1991235 citationsJournal Articlebronze Open Access

Authors

Thomas J. Moss · University of California, Los Angeles

C. Patrick Reynolds · UCLA Jonsson Comprehensive Cancer Center

Harland N. Sather · University of Southern California

Stephen G. Romansky · St. Jude Medical Center

G. Denman Hammond · University of Southern California

Robert C. Seeger · University of California, Los Angeles

Abstract

Immunocytologic analysis of bone marrow aspirates is more sensitive than conventional analysis in detecting tumor cells and provides prognostic information. The relations among marrow metastases, age at diagnosis, and clinical outcome illustrate the biologic heterogeneity of neuroblastoma.

Topics & Keywords

Neuroblastoma Research and Treatments Cancer therapeutics and mechanisms Cancer, Hypoxia, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 324, Issue 4, pp. 219-226

DOI: 10.1056/nejm199101243240403

Field-Weighted Citation Impact: 9.81