Human Growth Hormonelike Activity of Ovine Prolactin in Man.

s1 April 1963Human Growth Hormonelike Activity of Ovine Prolactin in Man.J. C. Beck, M.D., F.A.C.P., E. E. McGarry, M.D., F.A.C.P.J. C. Beck, M.D., F.A.C.P.Search for more papers by this author, E. E. McGarry, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-722_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGrowth hormone preparations from other than primate sources are biologically inactive in man. Recent chemical, biological, and immunological evidence suggests that human growth hormone is identical or similar to human prolactin. Therefore, the metabolic effect of a purified sheep prolactin preparation was studied in man. Three hypopituitary dwarfs on metabolic balance study were given human growth hormone and, subsequently, sheep prolactin. The sheep prolactin preparation was found to mimic the metabolic action of human growth hormone, producing nitrogen retention, hypercalciuria, and relative impairment of carbohydrate tolerance. One 18-year-old female with a bone age of 12 years and a prepubertal body... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal, Quebec (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGrowth and Pituitary Hormones 1 April 1963Volume 58, Issue 4Page: 722-722KeywordsBoneCarbohydratesGrowth hormoneHuman growth hormoneProlactin Issue Published: 1 April 1963 PDF DownloadLoading ...