Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs

201389 citationsJournal Article

Authors

Xia Li

Fan Wu · Anhui Medical University

Rui Sheng Xu · Wuxi Third People's Hospital

Wei Hu · Anhui Medical University

Dong Jiang · Wuxi Third People's Hospital

Cheng Ji · Wuxi Third People's Hospital

Fei Hu Chen · Anhui Medical University

Abstract

ASIC1a activation in endplate chondrocytes may trigger Ca(2+)-dependent proteases activity and signaling, which leads to apoptosis of endplate chondrocytes in IVDs.

Topics & Keywords

Ion Transport and Channel Regulation Spinal Cord Injury Research Nitric Oxide and Endothelin Effects

Publication Details

Published in: Expert Opinion on Therapeutic Targets

Volume 18, Issue 1, pp. 1-14

DOI: 10.1517/14728222.2014.859248

Field-Weighted Citation Impact: 3.36

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Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs

Authors

Abstract

Topics & Keywords

Publication Details