Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis

2014196 citationsJournal Articlehybrid Open Access

Authors

József Maléth · University of Szeged

Anita Balázs · University of Szeged

Petra Pallagi · University of Szeged

Zsolt Balla · University of Szeged

Balázs Kui · University of Szeged

Máté Katona · University of Szeged

Linda Judák · University of Szeged

Abstract

Based on studies of human, mouse, and guinea pig pancreata, alcohol disrupts expression and localization of the CFTR. This appears to contribute to development of pancreatitis. Strategies to increase CFTR levels or function might be used to treat alcohol-associated pancreatitis.

Topics & Keywords

Pancreatitis Pathology and Treatment Cystic Fibrosis Research Advances Pediatric Hepatobiliary Diseases and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gastroenterology

Volume 148, Issue 2, pp. 427-439.e16

DOI: 10.1053/j.gastro.2014.11.002

Field-Weighted Citation Impact: 16.42