Multiple Cytokines Are Released When Blood from Patients with Tuberculosis Is Stimulated with Mycobacterium tuberculosis Antigens

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Authors

Kathryn L. Kellar · Centers for Disease Control and Prevention

Jennifer Gehrke · Centers for Disease Control and Prevention

Stephen E. Weis · University of North Texas Health Science Center

Aida Mahmutovic-Mayhew · Oak Ridge Associated Universities

Blachy J. Dávila Saldaña · Centers for Disease Control and Prevention

Margan J. Zajdowicz · Great Lakes Science Center

Robin T. Scarborough

Abstract

Multiple cytokines are released when whole blood from patients with CCTB is stimulated with Mtb antigens. Measurement of multiple cytokine responses may improve diagnostic sensitivity for Mtb infection compared with assessment of IFN-γ alone.

Topics & Keywords

Tuberculosis Research and Epidemiology Mycobacterium research and diagnosis Infectious Diseases and Tuberculosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 6, Issue 11, pp. e26545-e26545

DOI: 10.1371/journal.pone.0026545

Field-Weighted Citation Impact: 4.77