Hybridoma Produces Protective Antibodies Directed Against the Sporozoite Stage of Malaria Parasite

1980496 citationsJournal Article

Authors

Nobuko Yoshida · Columbia University Irving Medical Center

Ruth S. Nussenzweig · New York University

P Potocnjak · Columbia University Irving Medical Center

Victor Nussenzweig · New York University

Masanori Aikawa · Case Western Reserve University

Abstract

Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research Trypanosoma species research and implications Glycosylation and Glycoproteins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Science

Volume 207, Issue 4426, pp. 71-73

DOI: 10.1126/science.6985745

Field-Weighted Citation Impact: 19.49