Use of an Anti–Interleukin-5 Antibody in the Hypereosinophilic Syndrome with Eosinophilic Dermatitis

Three patients with hypereosinophilia and severe eosinophilic dermatitis in whom a variety of conventional treatments were ineffective had a rapid response to infusions of a humanized anti–interleukin-5 antibody. None of the patients had evidence of a clonal T-cell disorder or a myeloproliferative disease.