Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer

2012268 citationsJournal Articlegold Open Access

Authors

Tangfeng Lv · Nanjing University

Dongmei Yuan · Nanjing University

Xiaohui Miao · Nanjing General Hospital of Nanjing Military Command

Yanling Lv · Nanjing General Hospital of Nanjing Military Command

Ping Zhan · Nanjing Chest Hospital

Xiaokun Shen · Nanjing University

Yong Song

Abstract

Over-expression of LSD1 was associated with poor prognosis in NSCLC, and promoted tumor cell proliferation, migration and invasion. These results suggest that LSD1 is a tumor-promoting factor with promising therapeutic potential for NSCLC.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Histone Deacetylase Inhibitors Research

UN Sustainable Development Goals

No poverty

Publication Details

Published in: PLoS ONE

Volume 7, Issue 4, pp. e35065-e35065

DOI: 10.1371/journal.pone.0035065

Field-Weighted Citation Impact: 9.53