Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.

1996166 citationsJournal Articlebronze Open Access

Authors

Francis M. Giardiello · Johns Hopkins Medicine

Gloria M. Petersen · Johns Hopkins University

Jill D. Brensinger · Johns Hopkins University

Michael C. Luce · Johns Hopkins University

M C Cayouette · Johns Hopkins University

Judith A. Bacon · Johns Hopkins Medicine

Susan V. Booker

Abstract

Hepatoblastoma occurs primarily in boys in FAP kindreds and is associated with germline APC mutation in the 5' end of the gene. However, the site of APC mutation cannot be used to predict occurrence of this extracolonic cancer in FAP pedigrees.

Topics & Keywords

Genetic factors in colorectal cancer Cancer Genomics and Diagnostics Colorectal Cancer Treatments and Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 39, Issue 6, pp. 867-869

DOI: 10.1136/gut.39.6.867

Field-Weighted Citation Impact: 2.00