Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis

2006119 citationsJournal Article

Authors

Hideo Kobayashi · Yokohama City University

Mitsuhiro Takeno · Yokohama City University

Tomoyuki Saito · Yokohama City University

Yukiko Takeda · Yokohama City University

Yohei Kirino · Yokohama City University

Koji Noyori · Yokohama City University

Takeshi Hayashi ·

Abstract

Our data demonstrate that HO-1 is expressed in RA synovial tissues and plays a regulatory role in the development of inflammation. The pharmacologic effects of auranofin depend, in part, on the levels of HO-1, suggesting that HO-1 induction is a novel therapeutic strategy for RA.

Topics & Keywords

Heme Oxygenase-1 and Carbon Monoxide Inflammasome and immune disorders Bone and Joint Diseases

Publication Details

Published in: Arthritis & Rheumatism

Volume 54, Issue 4, pp. 1132-1142

DOI: 10.1002/art.21754

Field-Weighted Citation Impact: 3.31

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Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis

Authors

Abstract

Topics & Keywords

Publication Details