Loeys–Dietz syndrome: a primer for diagnosis and management

2014567 citationsReviewhybrid Open Access

Authors

Gretchen MacCarrick · Johns Hopkins Medicine

James H. Black · Johns Hopkins Hospital

Sarah Bowdin · Hospital for Sick Children

Ismaı̈l El-Hamamsy · Montreal Heart Institute

Pamela A. Frischmeyer‐Guerrerio · Johns Hopkins Medicine

Anthony L. Guerrerio · Johns Hopkins University

Paul D. Sponseller

Abstract

Loeys-Dietz syndrome is a connective tissue disorder predisposing individuals to aortic and arterial aneurysms. Presenting with a wide spectrum of multisystem involvement, medical management for some individuals is complex. This review of literature and expert opinion aims to provide medical guidelines for care of individuals with Loeys-Dietz syndrome.

Topics & Keywords

Connective tissue disorders research Aortic aneurysm repair treatments Aortic Disease and Treatment Approaches

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genetics in Medicine

Volume 16, Issue 8, pp. 576-587

DOI: 10.1038/gim.2014.11

Field-Weighted Citation Impact: 29.44