Signal transduction and functional selectivity of F15599, a preferential post‐synaptic 5‐HT<sub>1A</sub>receptor agonist

2009126 citationsJournal Articlebronze Open Access

Authors

Adrian Newman‐Tancredi · Pierre Fabre (France)

J‐C Martel · Pierre Fabre (France)

M‐B Assié · Pierre Fabre (France)

Jaroslava Buritova · Pierre Fabre (France)

Emilie Lauressergues · Pierre Fabre (France)

Cristina Cosi · Pierre Fabre (France)

Peter Heusler ·

Abstract

F15599 showed a distinctive activation profiles for 5-HT(1A) receptor-mediated signalling pathways, unlike those of reference agonists and consistent with functional selectivity at 5-HT(1A) receptors. In rat, F15599 potently activated signalling in prefrontal cortex, a feature likely to underlie its beneficial effects in models of depression and cognition.

Topics & Keywords

Receptor Mechanisms and Signaling Neuroscience and Neuropharmacology Research Neurotransmitter Receptor Influence on Behavior

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 156, Issue 2, pp. 338-353

DOI: 10.1111/j.1476-5381.2008.00001.x

Field-Weighted Citation Impact: 3.02