AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER

19971,728 citationsJournal Article

Authors

David M. Turner · St Mary's Hospital

Denise Williams · University of Manchester

David Sankaran · University of Manchester

Mark Lazarus · University of Manchester

P. J. Sinnott · St Mary's Hospital

Ian V. Hutchinson · University of Manchester

Abstract

Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

Topics & Keywords

T-cell and B-cell Immunology Monoclonal and Polyclonal Antibodies Research NF-κB Signaling Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Journal of Immunogenetics

Volume 24, Issue 1, pp. 1-8

DOI: 10.1111/j.1365-2370.1997.tb00001.x

Field-Weighted Citation Impact: 13.20