Cellular and molecular mechanisms of action of bisphosphonates

2000848 citationsReview

Authors

Michael J. Rogers

Sharon Gordon · University of Aberdeen

Helena L. Benford · University of Aberdeen

Fraser P. Coxon · University of Aberdeen

Steven P. Luckman · University of Aberdeen

Jukka Mönkkönen · University of Eastern Finland

Julie C. Frith · University of Aberdeen

Abstract

Bisphosphonates are highly effective inhibitors of bone resorption that selectively affect osteoclasts. After more than 30 years of clinical use, their molecular mechanisms of action are only just becoming clear.

Topics & Keywords

Bone health and treatments Radiopharmaceutical Chemistry and Applications Boron Compounds in Chemistry

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 88, Issue S12, pp. 2961-2978

DOI: 10.1002/1097-0142(20000615)88:12+<2961::aid-cncr12>3.3.co;2-c

Field-Weighted Citation Impact: 14.21