Microparticles from Stored Red Blood Cells Activate Neutrophils and Cause Lung Injury after Hemorrhage and Resuscitation

2012148 citationsJournal Article

Authors

Ritha M. Belizaire · University of Cincinnati

Priya Prakash · University of Cincinnati

Jillian R. Richter · University of Cincinnati

Bryce R. H. Robinson · University of Cincinnati

Michael J. Edwards · University of Cincinnati

Charles C. Caldwell · University of Cincinnati

Alex B. Lentsch

Abstract

Stored packed RBC units contain increased numbers of RBC-derived MPs. These MPs appear to contribute to neutrophil priming and activation. The presence of MPs in stored units can be associated with adverse effects, including lung injury, after transfusion.

Topics & Keywords

Extracellular vesicles in disease Blood transfusion and management Thermal Regulation in Medicine

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American College of Surgeons

Volume 214, Issue 4, pp. 648-655

DOI: 10.1016/j.jamcollsurg.2011.12.032

Field-Weighted Citation Impact: 4.16