Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

2013655 citationsJournal Articlegreen Open Access

Authors

Jing Lin · Shanghai Jiao Tong University

Shouju Wang · National Institute of Biomedical Imaging and Bioengineering

Peng Huang · National Institute of Biomedical Imaging and Bioengineering

Zhe Wang · National Institute of Biomedical Imaging and Bioengineering

Shuiliang Chen · National Institute of Biomedical Imaging and Bioengineering

Gang Niu · National Institute of Biomedical Imaging and Bioengineering

Abstract

A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.

Topics & Keywords

Nanoplatforms for cancer theranostics Gold and Silver Nanoparticles Synthesis and Applications Advanced Nanomaterials in Catalysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: ACS Nano

Volume 7, Issue 6, pp. 5320-5329

DOI: 10.1021/nn4011686

Field-Weighted Citation Impact: 45.70