The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis

2015108 citationsJournal Articlegold Open Access

Authors

Guohua Lou · Zhejiang University

Yanning Liu · First Affiliated Hospital Zhejiang University

Shanshan Wu · First Affiliated Hospital Zhejiang University

Jihua Xue · Zhejiang University

Fan Yang · First Affiliated Hospital Zhejiang University

Haijing Fu · Zhejiang University

Min Zheng

Abstract

miR-34a plays an important role in the anti-tumor effects of querctin in HCC, miR-34a may be a tiemolecule between the p53 and SIRT1 and is composed of a p53/miR-34a/SIRT1 signal feedback loop, which could enhance apoptosis signal and significantly promote cell apoptosis.

Topics & Keywords

MicroRNA in disease regulation Circular RNAs in diseases Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 35, Issue 6, pp. 2192-2202

DOI: 10.1159/000374024

Field-Weighted Citation Impact: 4.57