Anti‐MuSK patient antibodies disrupt the mouse neuromuscular junction

2008173 citationsJournal Article

Authors

Stephen Reddel · Concord Repatriation General Hospital

William D. Phillips · Robert Bosch (India)

Abstract

IgG from anti-MuSK-positive patients can cause myasthenia gravis when injected into mice. This may be explained by a progressive reduction in the density of postsynaptic AChR combined with changes in the nerve terminal and its relation to the postsynaptic structure.

Topics & Keywords

Myasthenia Gravis and Thymoma Peripheral Neuropathies and Disorders Antifungal resistance and susceptibility

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 63, Issue 6, pp. 782-789

DOI: 10.1002/ana.21371

Field-Weighted Citation Impact: 6.57