Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment

2006208 citationsJournal Article

Authors

David J. Moore · University of California, San Diego

Eliezer Masliah · University of California, San Diego

Julie D. Rippeth · Neurobehavioral Research (United States)

Raúl González · University of Illinois Chicago

Catherine L. Carey · University of California, San Diego

Mariana Cherner · Neurobehavioral Research (United States)

Ronald J. Ellis

Abstract

As the anatomic distribution and temporal progression of neuropathologic changes appears to differ across individuals, it is important to consider both cortical and subcortical brain regions in studies of neuropathogenesis and treatment of HIV-related brain disease. Furthermore, combining information from several markers of neural injury provided the strongest association with degree of neurocognitive impairment during life.

Topics & Keywords

HIV Research and Treatment Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: AIDS

Volume 20, Issue 6, pp. 879-887

DOI: 10.1097/01.aids.0000218552.69834.00

Field-Weighted Citation Impact: 4.49