A Phase I, Two-center Study of the Pharmacokinetics and Pharmacodynamics of Dexmedetomidine in Children

2006234 citationsJournal Articlebronze Open Access

Authors

Guy C. Pétroz

Nancy Sikich

Jerrold Lerman · Strong Memorial Hospital

Abstract

The pharmacokinetics of dexmedetomidine in children are predictable with a terminal half-life of 1.8 h. Hemodynamic responses decreased with increasing doses of dexmedetomidine. Respiratory responses were maintained, whereas sedation was transient.

Topics & Keywords

Anesthesia and Sedative Agents Intensive Care Unit Cognitive Disorders Anesthesia and Neurotoxicity Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 105, Issue 6, pp. 1098-1110

DOI: 10.1097/00000542-200612000-00009

Field-Weighted Citation Impact: 9.23