Peroxisome Proliferator-Activated Receptor γ Activators Downregulate Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

2000170 citationsJournal Articlebronze Open Access

Authors

Kotaro Takeda · Kyushu University

Toshihiro Ichiki · Kyushu University

Tomotake Tokunou · Kyushu University

Yuko Funakoshi · Kyushu University

Naoko Iino · Kyushu University

Katsuya Hirano · Kyushu University

Hideo Kanaide · Kyushu University

Abstract

PPARgamma activators reduced the AT(1)-R expression and calcium response to Ang II in VSMCs. Downregulation of AT(1)-R may contribute to the inhibition of neointimal formation by PPARgamma activators.

Topics & Keywords

Peroxisome Proliferator-Activated Receptors Adipose Tissue and Metabolism Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 102, Issue 15, pp. 1834-1839

DOI: 10.1161/01.cir.102.15.1834

Field-Weighted Citation Impact: 2.99