St John's Wort: Effect on CYP3A4 activity

2000316 citationsJournal Article

Authors

Clinton Roby · National Institutes of Health Clinical Center

Abstract

Treatment with St John's Wort for 14 days resulted in significant increases in the urinary 6-beta-hydroxycortisol/cortisol ratio. This finding suggests that St John's Wort is an inducer of CYP3A4.

Topics & Keywords

Pharmacogenetics and Drug Metabolism Complementary and Alternative Medicine Studies Schizophrenia research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 67, Issue 5, pp. 451-457

DOI: 10.1067/mcp.2000.106793

Field-Weighted Citation Impact: 26.67