TSH Levels and Risk of Miscarriage in Women on Long-Term Levothyroxine: A Community-Based Study

2014133 citationsJournal Articlebronze Open Access

Authors

Peter Taylor · Cardiff University

Caroline Minassian · London School of Hygiene & Tropical Medicine

Anis Rehman · Akron General Medical Center

Ahmed Iqbal · University of Bristol

Mohd Shazli Draman · Cardiff University

William Hamilton · University of Exeter

Diana Clare Dunlop

Abstract

The majority of levothyroxine-treated women have early gestational TSH levels above the recommended targets (>2.5 mU/L) with a strong risk of miscarriage at levels exceeding 4.5 mU/L. There is an urgent need to improve the adequacy of thyroid hormone replacement in early pregnancy.

Topics & Keywords

Thyroid Disorders and Treatments Thyroid Cancer Diagnosis and Treatment Pituitary Gland Disorders and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 99, Issue 10, pp. 3895-3902

DOI: 10.1210/jc.2014-1954

Field-Weighted Citation Impact: 9.65