Changes in Mitochondrial DNA as a Marker of Nucleoside Toxicity in HIV-Infected Patients

2002572 citationsJournal Articlebronze Open Access

Authors

Hélène C. F. Côté · Providence Health Care

Zabrina L. Brumme · Providence Health Care

Kevin J.P. Craib · Providence Health Care

Christopher S. Alexander · Providence Health Care

Brian Wynhoven · Providence Health Care

Lillian Ting · Providence Health Care

Hubert Wong ·

Abstract

Mitochondrial DNA levels are significantly decreased in patients with symptomatic, nucleoside-related hyperlactatemia, an effect that resolves on the discontinuation of therapy.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 346, Issue 11, pp. 811-820

DOI: 10.1056/nejmoa012035

Field-Weighted Citation Impact: 62.90