Evaluation of characteristics of CD44+CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures

201369 citationsJournal Articlegold Open Access

Authors

Junsong Chen · Southeast University

Jing Wang · Southeast University

Dengyu Chen · Southeast University

Jie Yang · Simcere Pharmaceutical (China)

Cuiping Yang · Southeast University

Yunxia Zhang · Zhongda Hospital Southeast University

Hongyi Zhang ·

Abstract

Our assay demonstrated that human epithelial ovarian cancer CD44+CD117+cells possessed the properties of CSCs that exhibited more chemoresistance in the 3D culture than that of in 2D one. The 3D culture provides a realistic model for study of the CSC response to anticancer drugs.

Topics & Keywords

Cancer Cells and Metastasis Renal and related cancers 3D Printing in Biomedical Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cell Biology

Volume 14, Issue 1, pp. 7-7

DOI: 10.1186/1471-2121-14-7

Field-Weighted Citation Impact: 5.33