Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

2010183 citationsJournal Articlebronze Open Access

Authors

Sek Won Kong · Wenzhou Medical University

Yong Hu · Data61

Joshua W. K. Ho · University of Sydney

Sadakatsu Ikeda · Data61

Sean P. Polster · Data61

Ranjit John · Robert Bosch (Australia)

Jennifer L. Hall · Wenzhou Medical University

Abstract

Our data indicate that mRNA splicing is broadly altered in human heart disease and that patterns of aberrant RNA splicing accurately assign samples to control or disease classes.

Topics & Keywords

RNA Research and Splicing RNA modifications and cancer Cancer-related molecular mechanisms research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Cardiovascular Genetics

Volume 3, Issue 2, pp. 138-146

DOI: 10.1161/circgenetics.109.904698

Field-Weighted Citation Impact: 3.65