Effect of cimetidine and probenecid on pilsicainide renal clearance in humans

200051 citationsJournal Article

Authors

Tsuyoshi Shiga · Meiji Pharmaceutical University

Masayuki Hashiguchi · Tokyo Women's Medical University

Akinori Urae · Meiji Pharmaceutical University

Hiroshi Kasanuki · Meiji Pharmaceutical University

Tadaaki Rikihisa · SOUSEIKAI Global Clinical Research Center

Abstract

Pilsicainide appeared to be secreted by the active transport system for organic bases in the proximal tubule, and the excretion of pilsicainide was inhibited by cimetidine.

Topics & Keywords

Drug Transport and Resistance Mechanisms Pharmacogenetics and Drug Metabolism Analytical Methods in Pharmaceuticals

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Pharmacology & Therapeutics

Volume 67, Issue 3, pp. 222-228

DOI: 10.1067/mcp.2000.104018

Field-Weighted Citation Impact: 0.60