Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

20081,283 citationsJournal Articlebronze Open Access

Authors

Yujin Hoshida · Broad Institute

Augusto Villanueva · Icahn School of Medicine at Mount Sinai

Masahiro Kobayashi · Toranomon Hospital

Judit Peix · Icahn School of Medicine at Mount Sinai

Derek Y. Chiang · Harvard University

Amy L. Camargo · Broad Institute

Supriya Gupta ·

Abstract

We have demonstrated the feasibility of genomewide expression profiling of formalin-fixed, paraffin-embedded tissues and have shown that a reproducible gene-expression signature correlated with survival is present in liver tissue adjacent to the tumor in patients with hepatocellular carcinoma.

Topics & Keywords

Hepatocellular Carcinoma Treatment and Prognosis Cancer Genomics and Diagnostics Liver Disease Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 359, Issue 19, pp. 1995-2004

DOI: 10.1056/nejmoa0804525

Field-Weighted Citation Impact: 45.93