Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases

2005273 citationsJournal Articlebronze Open Access

Authors

Marie Pierik · Universitair Ziekenhuis Leuven

Sofie Joossens · Universitair Ziekenhuis Leuven

Kristel Van Steen · Harvard University

Nele Van Schuerbeek · Universitair Ziekenhuis Leuven

Robert Vlietinck · KU Leuven

Paul Rutgeerts · Universitair Ziekenhuis Leuven

Séverine Vermeire ·

Abstract

TLR2 and its cofactors TLR1 and TLR6 are involved in the initial immune response to bacteria by recognizing peptidoglycan. An association between nonsynonymous variants in the TLR1, -2, and -6 genes and extensive colonic disease in UC and CD was found. Our findings further highlight the role of an abnormal innate immune response in the pathogenesis of IBD.

Topics & Keywords

Immune Response and Inflammation Inflammatory Bowel Disease Mycobacterium research and diagnosis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Inflammatory Bowel Diseases

Volume 12, Issue 1, pp. 1-8

DOI: 10.1097/01.mib.0000195389.11645.ab

Field-Weighted Citation Impact: 6.41