Cofilin-1 Inactivation Leads to Proteinuria – Studies in Zebrafish, Mice and Humans

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Authors

Sharon Ashworth · University of Maine

Beina Teng · Medizinische Hochschule Hannover

Jessica Kaufeld · Mount Desert Island Biological Laboratory

Emily Happy Miller · Medizinische Hochschule Hannover

Irini Tossidou · Medizinische Hochschule Hannover

Christoph Englert · Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Frank Bollig

Abstract

Based on these in vitro and in vivo studies we concluded cofilin-1 is an essential regulator for actin filament recycling that is required for the dynamic nature of podocyte foot processes. Therefore, we describe a novel pathomechanism of proteinuria development.

Topics & Keywords

Renal Diseases and Glomerulopathies Chronic Kidney Disease and Diabetes Reproductive Biology and Fertility

UN Sustainable Development Goals

Life below water

Publication Details

Published in: PLoS ONE

Volume 5, Issue 9, pp. e12626-e12626

DOI: 10.1371/journal.pone.0012626

Field-Weighted Citation Impact: 3.59