Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

2012393 citationsJournal Article

Authors

Steve Bevan · St George's, University of London

Matthew Traylor · St George's, University of London

Poneh Adib‐Samii · St George's, University of London

Rainer Malik · St George's, University of London

Nicola Paul · University of Oxford

Caroline Jackson · St George's, University of London

Martin Farrall

Abstract

There is substantial heritability for ischemic stroke, but this varies for different stroke subtypes. Previous candidate gene associations contribute little to this heritability, but GWAS studies in related cardiovascular phenotypes are identifying robust associations. The heritability data, and data from GWAS, suggest detecting additional associations will depend on careful stroke subtyping.

Topics & Keywords

Genetic Associations and Epidemiology Neurological diseases and metabolism Nuclear Receptors and Signaling

Publication Details

Published in: Stroke

Volume 43, Issue 12, pp. 3161-3167

DOI: 10.1161/strokeaha.112.665760

Field-Weighted Citation Impact: 15.40

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Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations

Authors

Abstract

Topics & Keywords

Publication Details