Effects of Community-Wide Vaccination with PCV-7 on Pneumococcal Nasopharyngeal Carriage in The Gambia: A Cluster-Randomized Trial

2011132 citationsJournal Articlegold Open Access

Authors

Anna Roca · MRC Unit the Gambia

Philip C. Hill · University of Otago

John Townend · MRC Unit the Gambia

Uzo Egere · MRC Unit the Gambia

Martín Antonio · MRC Unit the Gambia

Abdoulie Bojang · MRC Unit the Gambia

Abiodun Akisanya ·

Abstract

Vaccination of Gambian children reduced vaccine-type pneumococcal carriage across all age groups, indicating a "herd effect" in non-vaccinated older children and adults. No significant serotype replacement was detected. Please see later in the article for the Editors' Summary.

Topics & Keywords

Pneumonia and Respiratory Infections Respiratory viral infections research Bacterial Infections and Vaccines

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS Medicine

Volume 8, Issue 10, pp. e1001107-e1001107

DOI: 10.1371/journal.pmed.1001107

Field-Weighted Citation Impact: 5.99