Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis

20111,155 citationsReviewbronze Open Access

Authors

Sven Trelle · University of Bern

Stephan Reichenbach · University of Bern

Simon Wandel · University of Bern

Pius Hildebrand · University of Bern

B. Tschannen · University of Bern

Peter M. Villiger · University of Bern

Matthias Egger ·

Abstract

Although uncertainty remains, little evidence exists to suggest that any of the investigated drugs are safe in cardiovascular terms. Naproxen seemed least harmful. Cardiovascular risk needs to be taken into account when prescribing any non-steroidal anti-inflammatory drug.

Topics & Keywords

Inflammatory mediators and NSAID effects Neuropeptides and Animal Physiology Eicosanoids and Hypertension Pharmacology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMJ

Volume 342, Issue jan11 1, pp. c7086-c7086

DOI: 10.1136/bmj.c7086

Field-Weighted Citation Impact: 97.73