Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin

20011,396 citationsJournal Articlebronze Open Access

Authors

Francesca Catella-Lawson · University of Pennsylvania

Muredach P. Reilly

Shiv Kapoor · University of Pennsylvania

Andrew J. Cucchiara · University of Pennsylvania

Susan DeMarco

Barbara Tournier

Sachin Vyas · University of Pennsylvania

Garret A. FitzGerald · University of Pennsylvania

Abstract

The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin. Treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin.

Topics & Keywords

Inflammatory mediators and NSAID effects Antiplatelet Therapy and Cardiovascular Diseases Synthesis of β-Lactam Compounds

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 345, Issue 25, pp. 1809-1817

DOI: 10.1056/nejmoa003199

Field-Weighted Citation Impact: 48.02