Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995572 citationsJournal Article

Authors

Yasundo Yamasaki · Taiho Oncology (United States)

Naosuke Matsuura · Taiho Oncology (United States)

Hidetaka Shozuhara · Taiho Oncology (United States)

Hiroshi Onodera · Taiho Oncology (United States)

Yasuto Itoyama · Taiho Oncology (United States)

Kyuya Kogure · Taiho Oncology (United States)

Abstract

Application of rhIL-1 beta augmented the increase of brain water content, and application of anti-IL-1 beta depressed the increase of water content. These results tended to correlate with the neutrophilic infiltration into the parenchyma. It thus appears that IL-1 beta may play an important role in ischemic brain damage after reperfusion.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Barrier Structure and Function Studies Immune Response and Inflammation

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Stroke

Volume 26, Issue 4, pp. 676-681

DOI: 10.1161/01.str.26.4.676

Field-Weighted Citation Impact: 19.24